| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Melatonin | 📋 | ✍ | ⛔ | | 35906194 | Melatonin Alleviates Heat Stress-induced the Impairment of Sertoli Cell by Reprogramming Glucose Metabolism |
| Curcumin | 📋 | ✍ | ⛔ | | 34801514 | Protective effects of dietary curcumin and astaxanthin against heat-induced ROS production and skeletal muscle injury in male and female C57BL/6J mice |
| L-Theanine | 📋 | ✍ | ⛔ | | 38414417 | The protective effect of L-theanine on the intestinal barrier in heat-stressed organisms |
| Selenium | 📋 | ✍ | ⛔ | | 36436303 | Dietary selenium levels modulates antioxidant, cytokine and immune response and selenoproteins mRNA expression in rats under heat stress condition |
| Vitamin C | 📋 | ✍ | ⛔ | | 36882274 | [Effects of heat exposure and vitamin C intervention on oxidative stress and blood pressure changes in treadmill rats] |
| EGCG | 📋 | ✍ | ⛔ | | 38705537 | EGCG alleviates heat-stress-induced fat deposition by targeting HSP70 through activation of AMPK-SIRT1-PGC-1α in porcine subcutaneous preadipocytes |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 36172616 | Effects of Moringa oleifera aqueous seed extracts on reproductive traits of heat-stressed New Zealand white female rabbits |
| Quercetin | 📋 | ✍ | ⛔ | | 38692425 | Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice |
| Baicalin | 📋 | ✍ | ⛔ | | 36270181 | Baicalin inhibits oxidative injures of mouse uterine tissue induced by acute heat stress through activating the Keap1/Nrf2 signaling pathway |
| Betaine | 📋 | ✍ | ⛔ | | 37863837 | Betaine ameliorates heat stress-induced apoptosis by affecting oxidative and endoplasmic reticulum stress in mouse Leydig cells |
| Ginseng | 📋 | ✍ | ⛔ | | 34146399 | Protective effects of ginsenoside Rc against acute cold exposure-induced myocardial injury in rats |
| L-Glutamine | 📋 | ✍ | ⛔ | | 37104726 | Glutamine alleviated heat-stress-induced damage of porcine intestinal epithelium associated with the mitochondrial apoptosis pathway mediated by heat shock protein 70 |
| Zinc | 📋 | ✍ | ⛔ | | 35959699 | Zinc supplementation prior to heat shock enhances HSP70 synthesis through HSF1 phosphorylation at serine 326 in human peripheral mononuclear cells |
| Astaxanthin | 📋 | ✍ | ⛔ | | 34801514 | Protective effects of dietary curcumin and astaxanthin against heat-induced ROS production and skeletal muscle injury in male and female C57BL/6J mice |
| Cannabidiol | 📋 | ✍ | ⛔ | | 27655472 | Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases |
| Cinnamon | 📋 | ✍ | ⛔ | | 33388379 | Network pharmacology-based research uncovers cold resistance and thermogenesis mechanism of Cinnamomum cassia |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 30684145 | Protective effect of dihydromyricetin on hyperthermia-induced apoptosis in human myelomonocytic lymphoma cells |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 35736412 | Serum Metabolomics Based on GC-MS Reveals the Antipyretic Mechanism of Ellagic Acid in a Rat Model |
| Genistein | 📋 | ✍ | ⛔ | | 36670986 | Genistein Promotes Anti-Heat Stress and Antioxidant Effects via the Coordinated Regulation of IIS, HSP, MAPK, DR, and Mitochondrial Pathways in Caenorhabditis elegans |
| Ginger | 📋 | ✍ | ⛔ | | 34503812 | Ginger root powder enhanced the growth productivity, digestibility, and antioxidative capacity to cope with the impacts of heat stress in rabbits |
| Isorhamnetin | 📋 | | | | 38553498 | Effects of isorhamnetin on liver injury in heat stroke-affected rats under dry-heat environments via oxidative stress and inflammatory response |
| L-Carnitine | 📋 | ✍ | ⛔ | | 35464382 | Exogenous L-carnitine Administration Ameliorates the Adverse Effects of Heat Stress on Testicular Hemodynamics, Echotexture, and Total Antioxidant Capacity in Rams |
| L-Citrulline | 📋 | ✍ | ⛔ | | 35791786 | L-citrulline prevents heat-induced mitochondrial dysfunction and cell injury through nitric oxide-mediated Drp1 inhibition in mouse C2C12 myoblasts |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 30811527 | N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis |
| Pine Bark | 📋 | ✍ | ⛔ | | 33077109 | Transcriptomic and biochemical effects of pycnogenol in ameliorating heat stress-related oxidative alterations in rats |
| Resveratrol | 📋 | ✍ | ⛔ | | 34614430 | Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress |
| Salidroside | 📋 | | | | 31448659 | Salidroside pretreatment protects against myocardial injury induced by heat stroke in mice |
| Sodium Bicarbonate | 📋 | ✍ | ⛔ | | 34590911 | Sodium bicarbonate ingestion mitigates the heat-induced hyperventilation and reduction in cerebral blood velocity during exercise in the heat |
| Taurine | 📋 | ✍ | ⛔ | | 38582816 | The effect of 8-day oral taurine supplementation on thermoregulation during low-intensity exercise at fixed heat production in hot conditions of incremental humidity |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 37511840 | Anti-Inflammatory, Antinociceptive, Antipyretic, and Gastroprotective Effects of Eurycoma longifolia Jack Ethanolic Extract |
| Acacetin | 📋 | | | | 25407486 | Antipyretic and antinociceptive potential of extract/fractions of Potentilla evestita and its isolated compound, acacetin |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 33532499 | Acetyl-L-Carnitine Induces Autophagy to Promote Mouse Spermatogonia Cell Recovery after Heat Stress Damage |
| Aged Garlic | 📋 | ✍ | ⛔ | | 32765777 | S -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway |
| Aloe Vera | 📋 | ✍ | ⛔ | | 37938932 | Isolation, preparation and investigation of leaf extracts of Aloe barbadensis for its remedial effects on tumor necrosis factor alpha (TNF-α) and interleukin (IL-6) by in vivo and in silico approaches in experimental rats |
| Andrographolide | 📋 | | | | 26151008 | Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata) |
| Ashitaba | 📋 | ✍ | ⛔ | | 30686791 | Angelica keiskei (Ashitaba) powder and its functional compound xanthoangelol prevent heat stress-induced impairment in sperm density and quality in mouse testes |
| Ashwagandha | 📋 | ✍ | ⛔ | | 34836854 | Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study |
| Asiaticoside | 📋 | | | | 22972613 | Antipyretic and anti-inflammatory effects of asiaticoside in lipopolysaccharide-treated rat through up-regulation of heme oxygenase-1 |
| Astragalosides | 📋 | ✍ | ⛔ | | 28578342 | Astragaloside-IV Protects Against Heat-induced Apoptosis by Inhibiting Excessive Activation of Mitochondrial Ca2+ Uniporter |
| Atractylodes | 📋 | ✍ | ⛔ | | 35785561 | Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway |
| Baicalein | 📋 | ✍ | ⛔ | | 35344833 | The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells |
| Barberry | 📋 | ✍ | ⛔ | | 23312115 | Berberis vulgaris root extract alleviates the adverse effects of heat stress via modulating hepatic nuclear transcription factors in quails |
| Bee Propolis | 📋 | ✍ | ⛔ | | 27746870 | The Ameliorative Potential of Ethanolic Extract of Propolis on Hematotoxicity and Structural Neuronal Damage in Hyperthermia-Exposed Rats |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 33615958 | β-Alanine Supplementation Attenuates the Neurophysiological Response in Animals Exposed to an Acute Heat Stress |
| Boron | 📋 | ✍ | ⛔ | | 32385716 | Boron Attenuates Heat Stress-Induced Apoptosis by Inhibiting Endoplasmic Reticulum Stress in Mouse Granulosa Cells |
| Caffeine | 📋 | ✍ | ⛔ | | 38433013 | Caffeine attenuates spermatogenic disorders in mice with induced chronic scrotal hyperthermia |
| Castor Oil | 📋 | ✍ | ⛔ | | 34836854 | Antipyretic and antinociceptive potential of Ricinus communis L. and Withania somnifera L. hydroalcoholic extracts in Wistar rats: A comparative study |
| Choline | 📋 | ✍ | ⛔ | | 34022514 | Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway |
| Cinnamaldehyde | 📋 | | | | 37994656 | Intragastric administration of cinnamaldehyde induces changes in body temperature via TRPA1 |
| Coptis Chinensis | 📋 | | ⛔ | | 28946610 | Coptidis Rhizoma Prevents Heat Stress-Induced Brain Damage and Cognitive Impairment in Mice |
| Elderberry | 📋 | ✍ | ⛔ | | 35088364 | Elderberry Diet Restores Spermatogenesis in the Transient Scrotal Hyperthermia-Induced Mice |
| Fat | 📋 | | | | 38226701 | Dietary-fat supplementation alleviates cold temperature-induced metabolic dysbiosis and barrier impairment by remodeling gut microbiota |
| Fisetin | 📋 | ✍ | ⛔ | | 34231174 | Protective Effects of Fisetin in the Mice Induced by Long-Term Scrotal Hyperthermia |
| Gardenia | 📋 | | ⛔ | | 31143120 | The Potential Antipyretic Mechanism of Gardeniae Fructus and Its Heat-Processed Products With Plasma Metabolomics Using Rats With Yeast-Induced Fever |
| Geniposide | 📋 | | | | 38387681 | Geniposide from Gardeniae Fructus exerts antipyretic effect in febrile rats through modulating the TLR4/NF-κB signaling pathway |
| Ginsenosides | 📋 | ✍ | ⛔ | | 32144882 | Ginsenoside Rd Ameliorates High Fat Diet-Induced Obesity by Enhancing Adaptive Thermogenesis in a cAMP-Dependent Manner |
| Goji Berry | 📋 | ✍ | ⛔ | | 34211569 | Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation |
| Graviola | 📋 | ✍ | ⛔ | | 30473869 | Protective effect of soursop ( Annona muricata linn.) juice on oxidative stress in heat stressed rabbits |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 33312479 | Effects of Short-Term Green Tea Extract Supplementation on VO 2 Max and Inflammatory and Antioxidant Responses of Healthy Young Men in a Hot Environment |
| Hawthorn | 📋 | ✍ | ⛔ | | 35164138 | Effect of Flavonoids in Hawthorn and Vitamin C Prevents Hypertension in Rats Induced by Heat Exposure |
| Hesperidin | 📋 | ✍ | ⛔ | | 32585605 | Protective Effects of Maternal Administration of Curcumin and Hesperidin in the Rat Offspring Following Repeated Febrile Seizure: Role of Inflammation and TLR4 |
| Holy Basil | 📋 | ✍ | ⛔ | | 26109769 | Pharmacological and Phytochemical Evaluation of Ocimum Sanctum Root Extracts for Its Antiinflammatory, Analgesic and Antipyretic Activities |
| Icariin | 📋 | ✍ | | | 33978900 | Icariin enhance mild hypothermia-induced neuroprotection via inhibiting the activation of NF-κB in experimental ischemic stroke |
| Jasmine | 📋 | | ⛔ | | 25479154 | Anti-inflammatory, analgesic and anti-pyretic activities of standardized root extract of Jasminum sambac |
| Jujube | 📋 | | ⛔ | | 36549370 | Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity |
| Kaempferol | 📋 | ✍ | ⛔ | | 36232461 | Probing the Potential Mechanism of Quercetin and Kaempferol against Heat Stress-Induced Sertoli Cell Injury: Through Integrating Network Pharmacology and Experimental Validation |
| Kudzu Root | 📋 | ✍ | ⛔ | | 35482150 | Water-Soluble Polysaccharides Extracted from Pueraria lobata Delay Aging of Caenorhabditis elegans under Heat Stress |
| L-Arginine | 📋 | ✍ | ⛔ | | 17693925 | L-arginine Causes Amelioration of Cerebrovascular Dysfunction and Brain Inflammation During Experimental Heatstroke |
| L-Proline | 📋 | ✍ | ⛔ | | 33540779 | Supplementation with Proline Improves Haemato-Biochemical and Reproductive Indicators in Male Rabbits Affected by Environmental Heat-Stress |
| Licorice Root | 📋 | ✍ | ⛔ | | 26626487 | Beneficial effects of Glycyrrhizae radix extract in preventing oxidative damage and extending the lifespan of Caenorhabditis elegans |
| Luteolin | 📋 | ✍ | ⛔ | | 29399124 | Effects of luteolin on regulatory proteins and enzymes for myocyte calcium circulation in hypothermic preserved rat heart |
| Maca Root | 📋 | ✍ | ⛔ | | 36102208 | The benefits of Maca (Lepidium meyenii) extract administration for male rabbits affected by environmental heat stress |
| Morin | 📋 | | | | 38219219 | Morin hydrate ameliorates heat-induced testicular impairment in a mouse model |
| Nattokinase | 📋 | ✍ | ⛔ | | 37483751 | A single dose of oral nattokinase accelerates skin temperature recovery after cold water immersion: A double-blind, placebo-controlled crossover study |
| NMN | 📋 | ✍ | ⛔ | | 35889753 | Exogenous Nucleotides Improved the Oxidative Stress and Sirt-1 Protein Level of Brown Adipose Tissue on Senescence-Accelerated Mouse Prone-8 (SAMP8) Mice |
| Nobiletin | 📋 | ✍ | | | 37695738 | Nobiletin ameliorates heatstroke-induced acute lung injury by inhibiting ferroptosis via p53/SLC7A11 pathway |
| Potassium | 📋 | ✍ | ⛔ | | 35004797 | Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial |
| Probiotics | 📋 | ✍ | ⛔ | | 33161525 | Hepatoprotective Effects of Selenium-Enriched Probiotics Supplementation on Heat-Stressed Wistar Rat Through Anti-Inflammatory and Antioxidant Effects |
| Puerarin | 📋 | ✍ | ⛔ | | 22401764 | Puerarin Exerts Antipyretic Effect on Lipopolysaccharide-Induced Fever in Rats Involving Inhibition of Pyrogen Production From Macrophages |
| Punicalagin | 📋 | ✍ | ⛔ | | 27055862 | Punicalagin induces Nrf2 translocation and HO-1 expression via PI3K/Akt, protecting rat intestinal epithelial cells from oxidative stress |
| Rosehip | 📋 | ✍ | ⛔ | | 33510877 | Cardioprotective effect of Rosa canina L. methanolic extract on heat shock induced cardiomyocyte injury: An experimental study |
| Rosmarinic Acid | 📋 | ✍ | | | 32901428 | The protective effect of rosmarinic acid on myotube formation during myoblast differentiation under heat stress |
| Royal Jelly | 📋 | ✍ | ⛔ | | 33627267 | Adaptogenic potential of royal jelly in reproductive system of heat stress-exposed male rats |
| Salt | 📋 | | ⛔ | | 35004797 | Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial |
| Schisandra | 📋 | ✍ | ⛔ | | 34831536 | Experimental Studies of the Effect of Schisandra chinensis Extract on the State of Adaptive Capabilities of Rats under Chronic and General Exposure to Cold |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 18395723 | Effect of Intestinal Production of Equol on Menopausal Symptoms in Women Treated With Soy Isoflavones |
| Spirulina | 📋 | ✍ | ⛔ | | 33801803 | Zinc and/or Selenium Enriched Spirulina as Antioxidants in Growing Rabbit Diets to Alleviate the Deleterious Impacts of Heat Stress during Summer Season |
| Tangeretin | 📋 | | | | 34580918 | Tangeretin promotes lifespan associated with insulin/insulin-like growth factor-1 signaling pathway and heat resistance in Caenorhabditis elegans |
| Tanshinone | 📋 | | | | 37610501 | Tanshinone IIA protects mouse testes from heat stress injury by inhibiting apoptosis and TGFβ1/Smad2/Smad3 signaling pathway |
| Tea Polyphenols | 📋 | | | | 37893767 | Influence of Heat Treatment on Tea Polyphenols and Their Impact on Improving Heat Tolerance in Drosophila melanogaster |
| Trehalose | 📋 | | ⛔ | | 36009683 | Trehalose Attenuates Oxidative Stress and Endoplasmic Reticulum Stress-Mediated Apoptosis in IPEC-J2 Cells Subjected to Heat Stress |
| TUDCA | 📋 | ✍ | ⛔ | | 26739509 | Testosterone production by a Leydig tumor cell line is suppressed by hyperthermia-induced endoplasmic reticulum stress in mice |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 35004797 | Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 35004797 | Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial |
| Vitamin E | 📋 | ✍ | ⛔ | | 33877689 | Effect of prolonged whole-body hyperthermia on adult male rat testes and the protective role of vitamin C and E: A histological and biochemical study |
| Vitamin K | 📋 | ✍ | ⛔ | | 35004797 | Effect of Multiple-Nutrient Supplement on Muscle Damage, Liver, and Kidney Function After Exercising Under Heat: Based on a Pilot Study and a Randomised Controlled Trial |
| Vitexin | 📋 | | | | 38005362 | Vitexin Regulates Heat Shock Protein Expression by Modulating ROS Levels Thereby Protecting against Heat-Stress-Induced Apoptosis |
